Esketamine Treatment in Dubai
Medically supervised nasal-spray treatment for eligible adults with treatment-resistant depression.
When traditional antidepressants have not brought you the relief you have been searching for, it is natural to feel discouraged. But there is hope. At Valens Clinic, we offer Esketamine nasal spray treatment, a breakthrough, evidence-based therapy designed for treatment-resistant depression. Administered in our safe, medically supervised environment by DHA-licensed psychiatric specialists, Esketamine offers a new pathway to healing for those who need it most. You do not have to navigate this journey alone.
Understanding esketamine therapy for depression
Esketamine (Spravato) is a rapid-acting antidepressant nasal spray that works differently from traditional SSRIs and other conventional antidepressant medications. While most antidepressants target serotonin pathways, esketamine acts on glutamate receptors in the brain, the most abundant neurotransmitter system involved in mood regulation and brain plasticity.
This FDA-approved treatment is indicated for treatment-resistant depression (TRD), where someone has not responded adequately to at least two different antidepressant treatments. Esketamine is used as an adjunctive therapy, meaning it is taken alongside your current oral antidepressant. By promoting new neural connections and supporting brain plasticity, esketamine can help restore pathways that depression has disrupted, often providing relief more rapidly than traditional antidepressant therapies
You can also read more about Esketamine’s benefits and limitations to better understand how this treatment is used in clinical care
Is esketamine nasal spray right for you?
Esketamine nasal spray is not the first step for depression treatment. It is usually considered when symptoms continue despite standard care. If any of the situations below sound familiar, a consultation with a DHA-licensed psychiatrist can help you understand whether esketamine for treatment-resistant depression is a suitable option
Traditional Treatments Are Not Working
You have tried two or more antidepressants and followed a treatment plan, but symptoms are still there. If you are experiencing treatment-resistant depression (TRD), esketamine may be worth exploring
Seeking a Faster Response
Traditional antidepressants can take weeks to work. Many people notice changes with esketamine within hours to days, although results vary
Persistent Symptoms Affect Daily Life
Ongoing low mood and emotional heaviness can make daily tasks feel harder and impact work and relationships. If depression is still limiting your life despite your efforts, specialised care may help
Medically Supervised Support
Esketamine is given in a clinical setting with structured monitoring. At Valens Clinic, it is administered and observed by DHA-licensed psychiatric specialists, with safety and comfort as priorities
Your esketamine treatment journey at Valens Clinic
Esketamine treatment at Valens Clinic is delivered through a structured, medically supervised process designed for safety, comfort, and personalised care. Here is what to expect at each step
Comprehensive Consultation
Your journey starts with a full psychiatric evaluation by our DHA-licensed specialists. We review your medical and psychiatric history, discuss previous treatment attempts, and assess whether esketamine is appropriate for your needs. This helps us build a personalised treatment plan
Administering the Nasal Spray
On treatment days, you will self-administer the esketamine nasal spray under the direct supervision of our medical team. Our specialists guide you through the process and remain available for support during administration
Comfortable Observation Period
After treatment, you will stay in our private clinic space for around two hours while our team monitors your vital signs and overall response. This observation period is an essential part of safe care. You will need someone to accompany you home, as you should not drive on treatment days
Meet Our Specialised Psychiatrists
At Valens Clinic, your Esketamine treatment is led by experienced, DHA-licensed psychiatrists who specialize in treatment-resistant depression and innovative psychiatric interventions. Our clinical team has received specialized training in Spravato administration and brings a compassionate, evidence-based approach to every patient’s care.
We understand that choosing a new treatment requires trust. Our specialists combine clinical excellence with genuine empathy, creating a therapeutic environment where you feel heard, supported, and confident in your care. Each member of our team is committed to staying at the forefront of psychiatric innovation while never losing sight of the person behind the diagnosis
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FAQs
Questions patients ask us
Short answers first. Open any question for the full detail, or browse the complete FAQ list.
Esketamine is different from ketamine as its S-enantiomer, delivered as a prescription nasal spray marketed as Spravato. Unlike traditional antidepressants that target serotonin, esketamine acts on glutamate receptors, which is why it can work faster for some patients with treatment-resistant depression.
Read the full answerA candidate for esketamine treatment is generally an adult with major depressive disorder who hasn’t responded to at least two different antidepressants. A DHA-licensed psychiatrist reviews medical history and current symptoms during consultation to confirm whether the treatment is appropriate.
Read the full answerEsketamine treatment requires medical supervision at every stage and is never intended for use outside a supervised clinical setting. At Valens Clinic, DHA-licensed psychiatrists oversee administration, and patients remain onsite for a monitored observation period while vital signs are checked.
Read the full answerCommon side effects include temporary dissociation, dizziness, nausea, sedation, and a rise in blood pressure. The effects usually appear during or shortly after the session and ease during the supervised observation period, so patients arrange alternate transport rather than driving home afterward.
Read the full answerEsketamine can start working within hours to days of a first session for many patients — faster than the weeks typically needed for standard antidepressants. Individual response varies, and esketamine works best as part of an ongoing, medically supervised treatment plan.
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